Cymbalta Alternatives to Consider — Talkspace

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Printed on: 30 Nov 2023

Alternatives to Cymbalta

Cymbalta (duloxetine) is a typical antidepressant for treating melancholy and anxiousness. It’s additionally typically prescribed for diabetic peripheral neuropathy and different medical circumstances that trigger ache, like arthritis, fibromyalgia, and continual again ache. Cymbalta is in a category of medicine generally known as serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs steadiness norepinephrine and serotonin ranges — neurotransmitters related to temper regulation and application — within the mind.

Whereas Cymbalta will be very efficient for some individuals, it’s not at all times the precise medicine for everybody. It’d trigger undesirable Cymbalta side effects, antagonistic drug interactions, not be efficient in relieving signs, otherwise you may simply be searching for pure options to Cymbalta use. Holistic remedy choices have gotten extra interesting and acquainted, whether or not mixed with medicine or remedy or when used independently. 

No matter your cause is for trying into Cymbalta options, we’re diving into every part you should find out about pure treatments and different medicine much like Cymbalta. 

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Different Drugs to Cymbalta

There are a number of medicines that could be viable options to Cymbalta for melancholy or different circumstances. Since each drug has distinctive traits, advantages, dangers, and negative effects, exploring every choice and checking with a healthcare supplier is important earlier than switching from Cymbalta.

1. Lexapro 

Lexapro (escitalopram) is an alternative choice to Cymbalta that is perhaps good for people who find themselves involved about Cymbalta’s results when used long-term. Lexapro is within the class of medicine referred to as selective serotonin reuptake inhibitors (SSRIs), which work by rising serotonin ranges within the mind to reinforce temper. There are various facets to contemplate when Cymbalta vs Lexapro.

Variations between Cymbalta and Lexapro: 

  • Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) whereas Lexapro is a selective serotonin reuptake inhibitor (SSRI).
  • Cymbalta is FDA-approved to deal with extra circumstances than Lexapro.
  • There is perhaps fewer antagonistic side effects of Lexapro than Cymbalta.
  • In some studies, Lexapro was simpler in treating main depressive dysfunction (MDD).

Similarities between Cymbalta and Lexapro: 

  • Each can deal with main depressive dysfunction (MDD) and anxiousness
  • Each medicine shouldn’t be used with the rest that will increase serotonin ranges.
  • Cymbalta and Lexapro shouldn’t be used with NSAIDs or different medicine that may trigger bleeding.

2.Effexor (venlafaxine)

Effexor is perhaps a great choice to discover because it’s one of many medicine much like Cymbalta. As a result of they’re in the identical class of antidepressants — SNRIs — they work equally.

Nonetheless, it’s necessary to notice that Effexor may cause important blood stress adjustments in comparison with different antidepressants. So, monitoring your BP often and consulting a medical skilled when taking this drug is important. 

Variations between Cymbalta and Effexor: 

  • Cymbalta is used to deal with extra medical circumstances.
  • Effexor will be an choice to deal with panic dysfunction and social anxiousness dysfunction.
  • Effexor is extra more likely to lower intercourse drive as a aspect impact.
  • Cymbalta is stronger and can be utilized in decrease doses.

Similarities between Cymbalta and Effexor: 

  • Cymbalta and Effexor are each SNRIs.
  • Each medicine can deal with MDD and generalized anxiousness dysfunction (GAD).
  • Shared negative effects embody dry mouth, drowsiness, lack of urge for food, and nausea.
  • Neither drug needs to be used along with monoamine oxidase inhibitors (MAOIs).

3. Prozac (fluoxetine)

Prozac is a typical and in style antidepressant medicine within the SSRI class of medicine. It’s prescribed to deal with main depressive dysfunction and obsessive-compulsive dysfunction. It’s additionally accepted to deal with the consuming dysfunction bulimia and panic dysfunction in adults.

Variations between Cymbalta and Prozac:

  • They’re in several courses of medicine — Cymbalta is an SNRI and Prozac is an SSRI.
  • Prozac is accepted to deal with extra psychological well being circumstances.
  • Prozac can be utilized to deal with some disordered consuming circumstances.
  • Cymbalta is accepted to deal with ache associated to some medical circumstances, whereas Prozac isn’t.

Similarities between Cymbalta and Prozac:

  • Cymbalta and Prozac can be utilized to deal with main depressive dysfunction.
  • Studies suggest that each medicine have related efficacy and security outcomes.

4. Wellbutrin (bupropion)

Wellbutrin is an antidepressant accepted to deal with main depressive dysfunction (MDD) and seasonal affective dysfunction (SAD). It’s additionally prescribed for smoking cessation. Within the norepinephrine and dopamine reuptake inhibitors (NDRIs) class of medicine, Wellbutrin has a few of the identical antagonistic results as Cymbalta, together with the potential to trigger dry mouth, dizziness, problem sleeping or insomnia, and nausea. 

Variations between Cymbalta and Wellbutrin:

  • Cymbalta and Wellbutrin belong to completely different courses of medicine.
  • Cymbalta could cause diarrhea and fatigue; Wellbutrin usually doesn’t.
  • Wellbutrin is perhaps a greater choice for individuals who expertise weight gain on Cymbalta.

Similarities between Cymbalta and Wellbutrin:

  • Each medicine are used to deal with sure forms of ache.
  • Each Cymbalta and Wellbutrin will be efficient in treating melancholy.
Drug Class of Medicine Treatable Circumstances Frequent Aspect Results
Cymbalta (duloxetine) SNRI Main depressive dysfunction
Normal anxiousness dysfunction
Nerve ache brought on by diabetes
Power muscle and joint ache
Fibromyalgia
Drowsiness
Constipation
Nausea
Dry mouth
Lack of urge for food
Elevated sweating
Lexapro (escitalopram) SSRI Main depressive dysfunction
Generalized anxiousness dysfunction
Dry mouth
Nausea
Issue sleeping
Confusion
Diarrhea or constipation
Headache
Sexual dysfunction
Dizziness or drowsiness
Effexor (venlafaxine) SNRI Despair
Generalized anxiousness dysfunction
Panic dysfunction
Social anxiousness dysfunction
Nausea
Dry mouth 
Dizziness 
Drowsiness
Constipation
Lack of urge for food
Blurred imaginative and prescient
Prozac (fluoxetine) SSRI Main depressive dysfunction
Obsessive-
compulsive dysfunction
Bulimia
Panic dysfunction
Bipolar melancholy
Nausea
Dizziness
Drowsiness
Lack of urge for food
Issue sleeping
sweating
Wellbutrin (bupropion) NDRIs Despair
Seasonal have an effect on dysfunction
Smoking cessation
Headache
Sweating
Sleep points
Dry mouth
Dizziness

Pure Alternate options to Cymbalta

Drugs like Cymbalta can work effectively for some individuals, however others may need a pure different. Whether or not it’s to keep away from negative effects or since you want a holistic method, there are a number of non-pharmaceutical Cymbalta options out there.

6. Omega-3 fatty acids

Omega-3 fatty acids are identified for coronary heart well being advantages and the power to help psychological well being. Omega-3s are important to mind operate and efficiency, and a few research has proven they’ll scale back signs of melancholy. Omega-3s are discovered naturally in meals sources like salmon or they’re out there as dietary supplements.

7. Vitamin D

Generally known as the sunshine vitamin, Vitamin D can enhance temper, which could make it a possible different to Cymbalta for melancholy. Studies have discovered that folks with melancholy typically have low vitamin D ranges, so supplementing may assist.

8. L-theanine

L-theanine is a singular amino acid present in inexperienced tea leaves. It’s gained reputation not too long ago on account of the calming impact it might have on the physique and thoughts. In research, l-theanine has been proven to be efficient in stress aid, temper enhancement, and improved sleep high quality.

9. Way of life adjustments 

Adjusting your way of life by specializing in wholesome habits could be a shocking different to Cymbalta that many individuals won’t think about. Implement the next into your days to see should you discover a discount in depressive signs and anxiousness.

  • Work out often: Research shows that getting the center charge up releases endorphins, generally known as the feel-good hormones. Even one thing so simple as strolling briskly day by day can enhance your temper.
  • Eat wholesome: Attempt to eat a balanced weight loss plan filled with nutrient-rich meals. It might not treatment your melancholy, however it might assist naturally elevate your temper.
  • Observe mindfulness: Conscious actions like meditation and journaling can change your mindset and enhance your temper.
  • Search remedy: Numerous studies have confirmed the improved efficacy of mixing remedy and drugs vs. utilizing one or the opposite alone.

“Remedy is a good way to develop perception into signs and analysis. It helps to facilitate consciousness and understanding of the problems that the individual is dealing with. You may as well study well being coping methods to assist handle signs. Typically medicine and remedy are mixed to deal with the individual and have a optimistic final result.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Concerns for Switching to a Cymbalta Different

If you happen to’re contemplating switching from a drugs like Cymbalta to a unique drug or a holistic remedy plan, there are a number of necessary elements to recollect. Discovering an acceptable different is just doable if it matches your distinctive wants and targets for enchancment.

Think about the next:

  • Why do you wish to transition from Cymbalta?
  • Do the negative effects of the drug outweigh any optimistic outcomes?
  • Have you ever talked to your physician about different drugs you’re presently taking?

“You will need to work carefully along with your psychiatrist when switching drugs to keep away from Cymbalta withdrawal. Focus on and be open about your signs and considerations along with your suppliers so they’re conscious of how you’re doing.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Discover the Proper Different with Talkspace 

If you happen to’re making an attempt to determine whether or not to vary drugs or take a holistic method to your remedy plan — or should you’re interested by combining drugs with remedy or non-pharmaceutical remedy choices — Talkspace is right here. 

Talkspace is a web based platform with a group of psychological well being professionals who can present remedy, prescriptions, and drugs administration.

We provide telehealth from the consolation of your private home as you make important selections about your medicine and remedy plan. Our group is right here that can assist you navigate the complexities of medicine adjustments.

Sources:

  1. Khan A, Bose A, Alexopoulos GS, Gommoll C, Li D, Gandhi C. Double-blind comparability of Escitalopram and duloxetine in??the??acute remedy of main??depressive dysfunction. Scientific Drug Investigation. 2007;27(7):481-492. doi:10.2165/00044011-200727070-00005. https://pubmed.ncbi.nlm.nih.gov/17563128/. Accessed September 24, 2023.  
  2. Kıvrak Y, Güvenç TS, Akbulut N, et al. Accelerated hypertension after venlafaxine utilization. Case Reviews in Psychiatry. 2014;2014:1-4. doi:10.1155/2014/659715. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190979/. Accessed September 24, 2023. 
  3. Eckert L, Lançon C. Duloxetine in contrast with fluoxetine and venlafaxine: Use of meta-regression evaluation for oblique comparisons. BMC Psychiatry. 2006;6(1). doi:10.1186/1471-244x-6-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1552056/. Accessed September 24, 2023.  
  4. Larrieu T, Layé S. Meals for temper: Relevance of dietary omega-3 fatty acids for melancholy and anxiousness. Frontiers in Physiology. 2018;9. doi:10.3389/fphys.2018.01047. https://www.frontiersin.org/articles/10.3389/fphys.2018.01047/full. Accessed September 24, 2023. 
  5. BIČÍKOVÁ M, DUŠKOVÁ M, VÍTKŮ J, et al. Vitamin D in anxiousness and affective issues. Physiological Analysis. Printed on-line 2015. doi:10.33549/physiolres.933082.https://www.biomed.cas.cz/physiolres/pdf/64%20Suppl%202/64_S101.pdf. Accessed September 24, 2023.
  6. White D, de Klerk S, Woods W, Gondalia S, Noonan C, Scholey A. Anti-stress, behavioural and magnetoencephalography results of an L-theanine-based nutrient drink: A randomised, double-blind, placebo-controlled, crossover trial. Vitamins. 2016;8(1):53. doi:10.3390/nu8010053. https://www.mdpi.com/2072-6643/8/1/53. Accessed September 24, 2023.
  7. Basso JC, Suzuki WA. The results of acute train on temper, cognition, neurophysiology, and neurochemical pathways: A Overview. Mind Plasticity. 2017;2(2):127-152. doi:10.3233/bpl-160040. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928534/. Accessed September 24, 2023.
  8. How do I select between medicine and remedy? American Psychological Affiliation. 2017. Accessed September 24, 2023. https://www.apa.org/ptsd-guideline/patients-and-families/medication-or-therapy

Talkspace articles are written by skilled mental health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our group of scientific specialists (therapists and psychiatrists of assorted specialties) to make sure content material is correct and on par with present business requirements.

Our purpose at Talkspace is to offer probably the most up-to-date, worthwhile, and goal data on psychological health-related matters as a way to assist readers make knowledgeable selections.

Articles comprise trusted third-party sources which are both immediately linked to within the textual content or listed on the backside to take readers on to the supply.

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