How To Talk About Major Depressive Disorder Stigma



Being a part of a Hispanic household, Marisol* stated that despair was not one thing that was mentioned at house—despair wasn’t well-understood or acceptable to speak about in her dad and mom’ or grandparents’ generations.

So when she began experiencing despair signs, she did what generations earlier than her had carried out: stayed quiet, though she privately acknowledged that there was one thing happening inside her. She discovered to stay together with her signs. Till, in her 40s, an sudden finish to a relationship and the load of being a working, single mom exacerbated her despair signs.

“My despair began to take extra of a toll on me,” she says. “I had emotions of worthlessness, misplaced a variety of weight, and I used to be drained the entire time. I misplaced curiosity in issues I as soon as loved like hanging out with my buddies, felt unhappy more often than not, and had issue concentrating.”

The turning level in her psychological well being journey occurred on a day when she wasn’t feeling effectively, shortly after her sudden breakup. That morning, she collapsed. This landed her within the hospital. It was an expertise she finally noticed as a blessing as a result of along with the assessments carried out to evaluate her bodily well being, she underwent a psychological well being analysis and was identified with a sort of despair referred to as Main Depressive Dysfunction (MDD).

MDD manifests as a posh set of 5 or extra signs, together with, however not restricted to, depressed temper, lack of curiosity, issue concentrating, extreme guilt, and low power. Nevertheless, everybody experiences MDD in a different way. Solely a well being care skilled can diagnose and deal with MDD.

For many individuals, a well being scare might be the worst second of their lives. For Marisol, she refers to it because the worst and finest second of her life as a result of it pushed her to confront her psychological well being and search the assistance she wanted.

Searching for assist

The journey to seek out an MDD remedy plan that was proper for her below the steerage of her well being care supplier took a while and was difficult, Marisol says. After her preliminary analysis, she tried varied remedy approaches and commenced seeing a licensed psychological well being counselor.

Marisol determined to hunt out a Latina psychiatrist pondering she would possibly join with somebody who may higher perceive her state of affairs and expertise.

“My new psychiatrist was extremely thorough,” she says. “What actually stood out to me was her dedication to my well-being. She persistently jogged my memory of follow-up appointments and took an actual curiosity in my psychological well being journey.”

Marisol’s psychiatrist took the time to assessment her remedy choices and really useful Trintellix® (vortioxetine), a prescription treatment utilized in adults to deal with MDD, which is a sort of despair. Trintellix has not been proven to be secure and efficient to be used in kids.

Marisol’s psychiatrist helped her perceive what she may anticipate whereas taking Trintellix and defined the dangers and advantages, like how Trintellix will increase the chance of suicidal ideas and actions in folks 24 years of age and youthful, particularly inside the first few months of remedy or when the dose is modified (of notice, Trintellix shouldn’t be permitted to be used in kids).

Scroll under for added Vital Security Info, together with Full Boxed WARNING for Suicidal Ideas and Actions. Click on right here for Medication Guide and focus on along with your physician.

Marisol’s psychiatrist additionally suggested her that she ought to name or get emergency assist instantly if she has new or sudden adjustments in temper, conduct, ideas or emotions, if she develops suicidal ideas or actions, or if she has or develops signs which might be new, worse, or fear her.

Together with security concerns, Marisol’s psychiatrist went over the constructive Trintellix outcomes from the medical trials in adults with MDD. In a number of short-term research carried out by Takeda Prescription drugs and Lundbeck, Trintellix was proven to assist cut back the general signs of MDD, primarily based on an total rating on a standardized despair score scale in comparison with sugar capsule.

Research additionally confirmed that Trintellix had a constructive impact on processing velocity (how rapidly an individual can precisely course of info) in grownup sufferers being handled with Trintellix for MDD. That is a side of cognitive perform that could be impaired in adults with MDD. The development in processing velocity could also be the results of an enchancment in despair. No research have been carried out to see whether or not Trintellix is any higher at enhancing processing velocity than different antidepressants.

Marisol’s psychiatrist additionally stated that she shouldn’t take Trintellix if she’s allergic to vortioxetine or every other elements in Trintellix, or if she’s taking, or has stopped taking inside the final 14 days, a drugs referred to as a Monoamine Oxidase Inhibitor (MAOI), together with the antibiotic linezolid or intravenous methylene blue.

Whereas antidepressants are recognized to be efficient primarily based on medical trials, there are potential uncomfortable side effects of antidepressants, together with nausea, vomiting, weight acquire, adjustments in sleep, treatment-emergent sexual dysfunction (TESD), and suicidal ideas and actions.

The commonest uncomfortable side effects of Trintellix are nausea, constipation, and vomiting. Severe potential uncomfortable side effects embrace serotonin syndrome, elevated danger of bleeding, manic episodes, discontinuation syndrome, eye issues, low ranges of salt (sodium) in your blood, and sexual issues. These will not be all of the doable uncomfortable side effects of Trintellix.

For almost 4 years, Marisol has been taking Trintellix for her MDD. She says it’s an necessary a part of her journey to assist preserve her psychological well being, along with staying linked together with her psychiatrist and sharing updates about how she is feeling.

Beginning conversations about despair

Virmarie Diaz Fernandez, MD is a board-certified psychiatrist specializing in offering culturally delicate and compassionate care to sufferers, particularly these within the Hispanic neighborhood. She shouldn’t be Marisol’s physician or psychiatrist.

“As a psychological well being care practitioner and a Hispanic girl who has seen the stigma of despair first-hand, I can’t emphasize sufficient the importance of fostering open and sincere dialogues between sufferers and well being care professionals,” says Dr. Diaz Fernandez. “I’ve seen many Hispanic girls assume the position of matriarch and understand despair as an indication of weak point. It’s necessary to me to create a secure house for my sufferers to really feel comfy sharing their private experiences. Speaking about their signs and historical past helps me tailor my suggestions.”

In Marisol’s neighborhood, despair continues to be a delicate subject, particularly amongst family and friends. “There’s nonetheless a variety of stigma surrounding despair,” Marisol says. That’s why she has initiated conversations together with her shut family and friends about psychological well being. She encourages them to precise their emotions. “It is important for individuals who could also be struggling to have the ability to discuss their feelings and know that it is okay to hunt assist when wanted,” she says. “That is particularly necessary in our tradition.”

She can be open together with her coworkers about her MDD analysis as a result of she needs to assist break the stigma round psychological well being in her office.

Marisol’s recommendation for somebody who resides with despair? “Don’t be afraid to ask questions. Don’t be afraid of what different folks suppose. Speak to a good friend or somebody you belief. It doesn’t matter what, they’re going to grasp and take you significantly.”

“The prevalent stigma surrounding psychological well being providers creates limitations to well-being,” says Dr. Diaz Fernandez. “It has been my skilled dedication to foster an area that encourages and helps the Hispanic neighborhood in embracing psychological well being. It’s necessary to strengthen that searching for help shouldn’t be an indication of weak point however a brave step ahead.”

To learn extra affected person tales like Marisol’s and get entry to different affected person assets, go to

*Marisol is a paid contributor for Takeda Prescription drugs and Lundbeck. Final identify withheld to guard private privateness.

Dr. Virmarie Diaz Fernandez is a board-certified psychiatrist practising in Georgia and Florida. She is a paid contributor for Takeda Prescription drugs and Lundbeck.

Prime Photograph: Marisol/W+G Artistic

What’s TRINTELLIX (vortioxetine)?
TRINTELLIX is a prescription medication utilized in adults to deal with a sure sort of despair referred to as Main Depressive Dysfunction (MDD). TRINTELLIX has not been proven to be secure and efficient to be used in kids.


Who mustn’t take TRINTELLIX?
Don’t begin or take TRINTELLIX in case you: 

  • are allergic to vortioxetine or any of the elements in TRINTELLIX
  • are taking, or have stopped taking inside the final 14 days, a drugs referred to as a Monoamine Oxidase Inhibitor (MAOI), together with the antibiotic linezolid or intravenous methylene blue

Don’t begin taking an MAOI for at the very least 21 days after you cease remedy with TRINTELLIX.

What ought to I inform my physician earlier than taking TRINTELLIX?
Earlier than taking TRINTELLIX, inform your physician: 

  • about all of your medical and different well being situations
  • in case you are pregnant or plan to develop into pregnant, since TRINTELLIX could hurt your unborn child. Taking TRINTELLIX throughout your third trimester could trigger your child to have withdrawal signs after start or to be at elevated danger for a critical lung drawback at start. Inform your physician instantly in case you develop into or suppose you’re pregnant whereas taking TRINTELLIX
  • in case you are breastfeeding or plan to breastfeed, since it isn’t recognized if TRINTELLIX passes into your breast milk

Inform your physician about all of the medicines you’re taking, together with prescription and over-the-counter medicines, nutritional vitamins, and natural dietary supplements, since TRINTELLIX and a few medicines could trigger critical uncomfortable side effects (or could not work as effectively) when taken collectively. Particularly inform your physician in case you take: medicines for migraine headache referred to as triptans; tricyclic antidepressants; lithium; tramadol, fentanyl, meperidine, methadone, or different opioids; tryptophan; buspirone; St. John’s Wort; medicines that may have an effect on blood clotting resembling aspirin, nonsteroidal anti-inflammatory medication (NSAIDs), warfarin; diuretics; medicines used to deal with temper, nervousness, psychotic, or thought issues, together with selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs); or medicines used to deal with seizures or convulsions.

What are the doable uncomfortable side effects of TRINTELLIX?
TRINTELLIX could trigger critical uncomfortable side effects, together with:

  • Serotonin syndrome: A doubtlessly life‐threatening drawback that may occur if you take TRINTELLIX with sure different medicines. Name your physician or go to the closest emergency room instantly when you’ve got any of the next indicators and signs of serotonin syndrome: agitation; seeing or listening to issues that aren’t actual; confusion; coma; quick heart-beat; adjustments in blood strain; dizziness; sweating; flushing; excessive physique temperature; shaking, stiff muscular tissues, or muscle twitching; lack of coordination; seizures; nausea, vomiting, diarrhea.
  • Elevated danger of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners could add to this danger. Inform your physician instantly about any uncommon bleeding or bruising.
  • Manic episodes: Manic episodes could occur in folks with bipolar dysfunction who take TRINTELLIX. Signs could embrace: tremendously elevated power; racing ideas; unusually grand concepts; speaking extra or sooner than normal; extreme issues sleeping; reckless conduct; extreme happiness or irritability.
  • Discontinuation syndrome: Abruptly stopping TRINTELLIX could trigger you to have critical uncomfortable side effects together with: nausea; sweating; adjustments in your temper; irritability and agitation; dizziness; electrical shock feeling; tremor; nervousness; confusion; headache; tiredness; issues sleeping; hypomania; ringing in your ears; seizures.
  • Eye issues: TRINTELLIX could trigger a sort of eye drawback referred to as angle-closure glaucoma in folks with sure different eye situations. You could wish to bear a watch examination to see in case you are in danger and obtain preventative remedy in case you are. Name your physician when you’ve got eye ache, adjustments in your imaginative and prescient, or swelling or redness in or across the eye.
  • Low ranges of salt (sodium) in your blood: Low sodium ranges in your blood that could be critical and should trigger loss of life can occur throughout remedy with TRINTELLIX. Aged folks and individuals who take sure medicines could also be at a better danger for creating low sodium ranges of their blood. Indicators and signs could embrace headache; issue concentrating; reminiscence adjustments; confusion; weak point and unsteadiness in your toes which may result in falls. In additional extreme or extra sudden instances, indicators and signs embrace: seeing or listening to issues that aren’t actual; fainting; seizures; coma; stopping respiration.
  • Sexual issues: Taking TRINTELLIX could trigger sexual issues. Signs in males could embrace: delayed ejaculation or incapability to have an ejaculation, decreased intercourse drive, or issues getting or holding an erection. Signs in females could embrace: decreased intercourse drive, or delayed orgasm or incapability to have an orgasm. Speak to your physician in case you develop any adjustments in your sexual perform or when you’ve got any questions or considerations about sexual issues throughout remedy with TRINTELLIX.

The commonest uncomfortable side effects of TRINTELLIX embrace:

  • nausea
  • constipation
  • vomiting

These will not be all of the doable uncomfortable side effects of TRINTELLIX. Inform your physician when you’ve got any facet impact that bothers you or doesn’t go away.

You might be inspired to report destructive uncomfortable side effects of pharmaceuticals to the FDA. Go to or name 1‐800‐FDA‐1088.

For added Vital Security Info, click on right here for Medication Guide, and focus on along with your physician.

TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Workplace and used below license by Takeda Prescription drugs America, Inc. TAKEDA and the TAKEDA emblem are registered emblems of Takeda Pharmaceutical Firm Restricted. ©2024 Takeda Prescription drugs U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327). US-VOR-1419v1.0 03/24


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